Summary : To evaluate the association between severe hypomagnesemia and the low-grade inflammatory response in subjects with metabolic syndrome (MetS), ninety-eight individuals with new diagnosis of MetS were enrolled in a cross-sectional study. Pregnancy, smoking, alcohol intake, renal damage, hepatic disorders, infectious or chronic inflammatory diseases, malignancy, use of diuretics, statins, calcium antagonist, antioxidants, vitamins, anti-inflammatory drugs, or previous oral magnesium supplementation were exclusion criteria. According serum magnesium levels, participants were assigned to the following groups: 1) severe hypomagnesemia (≤1.2 mg/dL)\; 2) hypomagnesemia (>1.2≤1.8 mg/dL)\; 3) Normal serum magnesium levels (>1.8 mg/dL). The low-grade inflammatory response was defined by elevation of serum levels of (CRP;1.0 ≤10.0 mg/L) or TNF-alpha (TNF-α ≥3.5 pg/mL). Severe hypomagnesemia, hypomagnesemia, and normomagnesemia were identified in 21 (21.4%), 38 (38.8%), and 39 (39.8%) individuals. The ORs, adjusted by WC, showed that severe hypomagnesemia (OR: 8.1\; CI 95%: 3.6-19.4 and OR: 3.7\; CI 95%: 1.1-12.1), but not hypomagnesemia (OR: 1.8\; CI 95%: 0.9-15.5 and OR: 1.6\; CI 95%: 0.7-3.6), was strongly associated with elevated CRP and TNF-α levels, and that normomagnesemia exhibited a protective role (OR: 0.32\; CI 95%: 0.1-0.7 and OR: 0.28\; CI 95%: 0.1-0.6) for elevation of CRP and TNF-α. Results of this study show that, in subjects with MetS, severe hypomagnesemia, but not hypomagnesemia, is associated with elevated concentrations of CRP and TNF-α.
http://www.jle.com/en/revues/bio_rech/mrh/e-docs/00/04/69/2E/resume.phtml
What's the story here? Since you don't get magnesium in your water any longer, you likely need to supplement. Good news? It's easy and cheap to do! http://www.amazon.com/s/ref=nb_sb_noss?url=search-alias%3Daps&field-keywords=natural+calm
The 16oz bottle lasts months. The Eades and Robb Wolf advocate supplementing this mineral, with the recommendation that it be taken before bedtime as a natural "calming" or "soothing" effect. However, beware, too much will create the Milk of Magnesia effect, go easy at first, and add more to discovery how much you can tolerate.
http://www.jle.com/en/revues/bio_rech/mrh/e-docs/00/04/69/2E/resume.phtml
What's the story here? Since you don't get magnesium in your water any longer, you likely need to supplement. Good news? It's easy and cheap to do! http://www.amazon.com/s/ref=nb_sb_noss?url=search-alias%3Daps&field-keywords=natural+calm
The 16oz bottle lasts months. The Eades and Robb Wolf advocate supplementing this mineral, with the recommendation that it be taken before bedtime as a natural "calming" or "soothing" effect. However, beware, too much will create the Milk of Magnesia effect, go easy at first, and add more to discovery how much you can tolerate.
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