Monday, September 24, 2012

Indicators For Insulin Resistance



Lipid accumulation product (LAP) is an index, which combines waist circumference (WC) and triglyceride (TG) reflecting lipid accumulation. The aims of the study were to explore the relationship between LAP and insulin resistance (IR) and to assess whether LAP was superior to WC and body mass index (BMI) in identifying IR.


The study was cross-sectional and included 2524 non-diabetic subjects from China. The blood pressure (BP), anthropometric measurements, glucose levels, insulin levels and a fasting lipid profile were measured. BMI, the homeostasis model assessment of IR (HOMA-IR) and LAP were calculated.


In both sexes, BP, BMI, total cholesterol (TC), non high-density lipoprotein cholesterol (non-HDL-C), HOMA-IR, fasting and postprandial glucose levels increased across LAP quartiles (P<0 .001=".001" across="across" cholesterol="cholesterol" decreased="decreased" hdl="hdl" i="i" lap="lap" levels="levels" quartiles="quartiles" while="while">P
<0 .001=".001" analysis="analysis" and="and" bmi="bmi" both="both" correlated="correlated" correlation="correlation" demonstrated="demonstrated" hdl-c="hdl-c" homa-ir="homa-ir" i="i" in="in" lap="lap" non-hdl-c="non-hdl-c" pearson="pearson" s="s" sexes="sexes" tg="tg" that="that" was="was" wc="wc" with="with">P<0 .001=".001" a="a" analysis="analysis" and="and" bmi="bmi" demonstrated="demonstrated" greater="greater" had="had" homa-ir="homa-ir" impact="impact" lap="lap" multivariate="multivariate" on="on" p="p" than="than" that="that" wc.="wc.">


LAP is closely associated with HOMA-IR and is a powerful index that outperforms BMI and WC in identifying IR in non-diabetic individuals.

The BLUF:  BMI based measures do not indicate poor health (as measured by insulin resistance) as well as an index of waist circumference and triglyceride levels.   And why wouldn't it?  Waist circumference changes and decreasing triglycerides are hall marks of carb restrictions.

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