Interesting prospective study - meaning they used existing studies and examined the data to prospect for previously undiscovered relationships - which shows consistency with the carbohydrate hypothesis. Would be interesting to dig into the study more and find out if they studied indicators like fasting insulin levels and could document a relationship between those and the carb/GI pattern.
http://www.ajcn.org/cgi/content/abstract/91/6/1764
Results: During a median of 12 y of follow-up, 1943 incident MI cases occurred. There was a nonsignificant inverse association between substitution of carbohydrates with low-GI values for SFAs and risk of MI [hazard ratio (HR) for MI per 5% increment of energy intake from carbohydrates: 0.88; 95% CI: 0.72, 1.07). In contrast, there was a statistically significant positive association between substitution of carbohydrates with high-GI values for SFAs and risk of MI (HR: 1.33; 95% CI: 1.08, 1.64). There was no association for carbohydrates with medium-GI values (HR: 0.98; 95% CI: 0.80, 1.21). No effect modification by sex was observed.
Conclusion: This study suggests that replacing SFAs with carbohydrates with low-GI values is associated with a lower risk of MI, whereasreplacing SFAs with carbohydrates with high-GI values is associated with a higher risk of MI.
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