Thursday, December 19, 2013

Mercola - Fructose and Cancer

Studies have shown that different sugars are metabolized using different metabolic pathways, and this is of MAJOR consequence when it comes to feeding cancer and making it proliferate. Three years ago, researchers published findings showing that fructose is readily used by cancer cells to increase their proliferation.6 Cancer cells did not respond to glucose in the same manner.
In this case, the cancer cells used were pancreatic cancer, which is typically regarded as the most deadly and universally rapid-killing form of cancer. According to the authors:
"Traditionally, glucose and fructose have been considered as interchangeable monosaccharide substrates that are similarly metabolized, and little attention has been given to sugars other than glucose. However, fructose intake has increased dramatically in recent decades and cellular uptake of glucose and fructose uses distinct transporters.
Here, we report that fructose provides an alternative substrate to induce pancreatic cancer cell proliferation. Importantly, fructose and glucose metabolism are quite different; in comparison with glucose, fructose... is preferentially metabolized via the nonoxidative pentose phosphate pathway to synthesize nucleic acids and increase uric acid production.
These findings show that cancer cells can readily metabolize fructose to increase proliferation. They have major significance for cancer patients given dietary refined fructose consumption, and indicate that efforts to reduce refined fructose intake or inhibit fructose-mediated actions may disrupt cancer growth." [Emphasis mine]

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