Children with severe therapy-resistant asthma (STRA) may have poorer lung function and worse symptoms compared to children with moderate asthma, due to lower levels of vitamin D in their blood, according to researchers in London. Lower levels of vitamin D may cause structural changes in the airway muscles of children with STRA, making breathing more difficult. The study provides important new evidence for possible treatments for the condition.
The findings were published online ahead of the print edition of the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine.
“This study clearly demonstrates that low levels of vitamin D are associated with poorer lung function, increased use of medication, worse symptoms and an increase in the mass of airway smooth muscle in children with STRA,” said Atul Gupta, MRCPCH, M.D., a researcher from Royal Brompton Hospital and the National Heart and Lung Institute (NHLI) at Imperial College and King’s College London. “It is therefore plausible that the link between airway smooth muscle mass and lung function in severe asthma may be partly explained by low levels of vitamin D.”
While most children with asthma can be successfully treated with low doses of corticosteroids, about 5 to 10 percent of asthmatic children do not respond to standard treatment. These children have severe therapy-resistant asthma, or STRA, experience more asthma episodes and asthma-related illnesses, and require more healthcare services, than their treatment-receptive peers.
The article concludes:
“The determination of the exact mechanism between low vitamin D and airway changes that occur in STRA will require intervention studies,” Dr. Gupta said. “Hopefully, the results of this and future studies will help determine a new course of therapy that will be effective in treating these children.”
Link to original article: http://www.thoracic.org/media/press-releases/resources/blue-201107-1239oc.pdf
http://www.newswise.com/articles/vitamin-d-deficiency-linked-with-airway-changes-in-children-with-severe-asthma
This seems like another piece in the paleolithic perspective of human wellness. Take an organism that adapted over a long, long time to the various climates of the planet, and drastically change that organism's living conditions in a relatively short period of time, and there will be consequences. Since we generally don't get enough sun, it is estimated that 90% of us are vitamin D deficient.
I did a summer experiment to see what my non-augmented D level will be after a summer's worth of exposure way down here in Tennessee. Now that the sun's retreating and the days are short and my body will even more fully covered by clothese, it's time to supplement.
The findings were published online ahead of the print edition of the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine.
“This study clearly demonstrates that low levels of vitamin D are associated with poorer lung function, increased use of medication, worse symptoms and an increase in the mass of airway smooth muscle in children with STRA,” said Atul Gupta, MRCPCH, M.D., a researcher from Royal Brompton Hospital and the National Heart and Lung Institute (NHLI) at Imperial College and King’s College London. “It is therefore plausible that the link between airway smooth muscle mass and lung function in severe asthma may be partly explained by low levels of vitamin D.”
While most children with asthma can be successfully treated with low doses of corticosteroids, about 5 to 10 percent of asthmatic children do not respond to standard treatment. These children have severe therapy-resistant asthma, or STRA, experience more asthma episodes and asthma-related illnesses, and require more healthcare services, than their treatment-receptive peers.
The article concludes:
“The determination of the exact mechanism between low vitamin D and airway changes that occur in STRA will require intervention studies,” Dr. Gupta said. “Hopefully, the results of this and future studies will help determine a new course of therapy that will be effective in treating these children.”
Link to original article: http://www.thoracic.org/media/press-releases/resources/blue-201107-1239oc.pdf
http://www.newswise.com/articles/vitamin-d-deficiency-linked-with-airway-changes-in-children-with-severe-asthma
This seems like another piece in the paleolithic perspective of human wellness. Take an organism that adapted over a long, long time to the various climates of the planet, and drastically change that organism's living conditions in a relatively short period of time, and there will be consequences. Since we generally don't get enough sun, it is estimated that 90% of us are vitamin D deficient.
I did a summer experiment to see what my non-augmented D level will be after a summer's worth of exposure way down here in Tennessee. Now that the sun's retreating and the days are short and my body will even more fully covered by clothese, it's time to supplement.
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