Sunday, January 15, 2012

Note on Cancer Ketone Relationship


Interesting collection of notes which is consistent with other materials I've read.  It makes a case for intermittent fasting, low carb intake most days, and in short - comports well with the Paleolithic model of nutrition.
Thomas Seyfried–“Ketone Bodies and Cancer”
  • Most brain tumors are untreatable and patients die from the pressure build-up
  • Calorie restriction is necessary for treating brain tumors
  • The mitochondria are dysfunctional in human brain tumors
  • Otto Warburg noted that cancer leads to irreversible damage
  • Tumor cells are unable to shift from feeding on glucose to ketones
  • Cancer is more of a metabolic disease than a genetic one
  • There’s an 80% reduction in tumor weight when calorie-restricted
  • Calorie-restriction one of the most powerful therapies for killing cancer cells
  • As glucose is decreased, cancer cells reduce as well
  • A low-carb, calorie-restricted diet is better than the best drug therapy for cancer
  • Ketogenic calorie-restricted diets have reduced brain tumors in mice and humans
  • Blood glucose remains too high on an unlimited calories low-carb diet to treat cancer
  • Calorie-restricted low-carb diets create adequate ketones for treating brain tumors
  • Ketogenic, calorie-restricted diets don’t cure cancer, but they come close
  • Tumors can’t grow when calories are cut to create ketones
  • Limiting carbs and calories puts you in the zone of managing tumor growth
  • Brain cancer in children can be treated with ketogenic diets by reducing glucose
  • Avoid radiation therapy if all all possible–ketogenic, calorie-restricted diet is best for cancer
Dr. Eugene Fine–“Reduced Carbohydrates in Aggressive Resistant Tumors (RECHARGE Trial)”
  • Not all cancers are dependent on glucose for growth, including prostate cancer
  • Hyperinsulinemia is a major cancer risk factor–that’s why reducing insulin in paramount
  • It’s plausible that reducing insulin secretion could inhibit cancer growth
  • The typical American diet contains 300-400g carbs daily–spiking insulin
  • Cut the carbs and you’ll cut the insulin and reduce your cancer risk
  • You don’t want an insulin knockout (Type 1 diabetes), but rather an insulin knockdown
  • A low-carb diet provides the proper control of insulin without eliminating the good it does
  • Reduced carb diets have not demonstrated adverse effects up to 2 years as a medical therapy
  • Humans were built as hunter-gatherers to be in a ketotic state most of the time
  • Fasting is in our ancestral biochemistry with no ill effects
  • There is no known dietary requirement for carbohydrate in your diet
  • Grains and vegetables are only a relatively recent addition to the human diet
  • A very low-carb diet changes the metabolic environment where cancer would grow
  • Too many people are living outside of a sustained ketogenic state leading to more cancer
  • RECHARGE Trial used very low-carb diet on 10 patients who failed on chemotherapy
  • The study placed the participants on a very low-carb ketogenic diet for 28 days
  • Average daily intake consumed by study patients was 27g carbs and 1236 daily
  • All of the study participants were ketotic
  • Future direction of research will be a larger study using ketogenic diets–funding needed





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