The research shows that aspartame and other 'fake' sweetners can stimulate the 'anticipatory' insulin spike - a body used to big doses of sugar starts the insulin as self defense prior to ingestion, again when the food hits the mouth, and then again as blood sugar rises. It's a defense mechanism kind of like pavlov's dogs learned to salivate to the bell sound. So folks who too much sugars (average American - 150#/year) probably are not helping a ton by using aspartame etc.
I don't think one diet coke/day will kill you. That's what I shoot for as a max, it's a good day if drink none.
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