http://www.thelivinlowcarbshow.com/shownotes/1326/chris-masterjohn-on-cholesterol-episode-314/
Chris Masterjohn weighs in on Jimmy's great podcast, and provides a model for oxidation that is "scientifically valid and accessible to the common man." His model - oxidation breaks molecules, so a human with oxidative damage has an excess of broken molecules infused in the cells/bloodstream. The oxidized, broken cells are like broken glass on a kitchen floor, and cause damage to surrounding tissues, and require cleanup. The result is a hyperactive immune system, which is so busy cleaning up damaged cells, it cannot take care of regular business as it should, AND may be causing unintended damage to normal tissues through chronic inflammatory response. So, imagine that you are consuming a lot of easily oxidized poly unsaturated fatty acids (PUFAs - seed oils and worse, hydrogenated oils), and your system becomes saturated with all that oxidized junk - it just can't be good, and the evidence indicates it is not, which is why efforts to move people to PUFAs vice saturated fats have not proved to be an effected measure to reduce CVD.
Chris also does a good job of clarifying the difference between the diet/heart hypothesis and the lipid hypothesis. The diet/heart hypothesis is that eating saturated fats and cholesterol results in higher serum levels of cholesterol and therefore contribute to CVD. The lipid hypothesis proposes a connection between plasma cholesterol level and the development of coronary heart disease.
In summary, this is another good session with Jimmy Moore. More of Chris' writing can be found on the Weston A. Price Foundation web site - http://www.westonaprice.org/blogs/blogger/CMASTERJO/ - this dude's got a big brain.
For a great survey of aging, oxidation and low carb diets, see this very detailed post by Dr. Mike Eades - http://www.proteinpower.com/drmike/low-carb-library/low-carb-diets-reduce-oxidative-stress/
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