YOU Are A Fructose Mutant

The mutation evolved 15 million years ago, during a period of starvation. One hundred percent of us have it.

While many of the details have yet to be published, Johnson said that the mutation led to an increase in how much uric acid our bodies produce after eating fructose, while also lengthening the amount of time that uric acid sticks around after a sweet treat.

The result, he said, is inflammation and an increased ability for cells to become fat. In other words, uric acid works within cells to amplify sugar's ability to cause obesity.

Even on a calorie-restricted diet, he said, animals that eat too much sugar develop insulin resistance, an early sign of diabetes. Other trials in people have shown that lowering uric acid levels lowered their blood pressure.
http://news.discovery.com/human/sugar-fructose-obesity-diabetes.html
The premise: the adaptation that saved us in times past is killing us in the age of nearly costless sugars.