How Much Do You Want That Diet Drink?

APM is metabolized in the gastrointestinal tract by

esterases and peptidases into three components: the amino

acids phenylanine and aspartic acid, and methanol [Ranney

et al., 1976].APMcan be also absorbed into the mucosal cells

prior to hydrolysis and then metabolized within the cell to its

three components which then enter circulation [Mattews,

1984]. Methanol is not subject to metabolism within the

enterocyte and rapidly enters the portal circulation and is

oxidized in the liver to formaldehyde, an highly reactive

chemical which strongly binds to proteins [Haschemeyer and

Haschemeyer, 1973] and nucleic acids [Metzler, 1977]

forming formaldehyde adducts. In a study, in which APM,

14C-labeled in the methanol carbon, was given orally to

adult male Wistar rats for 10 days, it was shown that the

carbon adducts of protein and DNA could have been

generated only from formaldehyde derived from APM

methanol. Moreover, it was suggested that the amount of

formaldehyde adducts may be cumulative [Trocho et al.,

1998].
http://www.ramazzini.it/ricerca/pdfUpload/APM%20administered%20in%20feed_Am.J.Ind.Med_2010.pdf

I've downed far too much of this stuff over the last 30 years.