Tuesday, March 8, 2011

How Much Do You Want That Diet Drink?

APM is metabolized in the gastrointestinal tract by
esterases and peptidases into three components: the amino
acids phenylanine and aspartic acid, and methanol [Ranney
et al., 1976].APMcan be also absorbed into the mucosal cells
prior to hydrolysis and then metabolized within the cell to its
three components which then enter circulation [Mattews,
1984]. Methanol is not subject to metabolism within the
enterocyte and rapidly enters the portal circulation and is
oxidized in the liver to formaldehyde, an highly reactive
chemical which strongly binds to proteins [Haschemeyer and
Haschemeyer, 1973] and nucleic acids [Metzler, 1977]
forming formaldehyde adducts. In a study, in which APM,
14C-labeled in the methanol carbon, was given orally to
adult male Wistar rats for 10 days, it was shown that the
carbon adducts of protein and DNA could have been
generated only from formaldehyde derived from APM
methanol. Moreover, it was suggested that the amount of
formaldehyde adducts may be cumulative [Trocho et al.,
1998].
http://www.ramazzini.it/ricerca/pdfUpload/APM%20administered%20in%20feed_Am.J.Ind.Med_2010.pdf

I've downed far too much of this stuff over the last 30 years.

No comments:

Post a Comment